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CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence
Cellular senescence has causative links with ageing and age-related diseases, however, it remains unclear if progeroid factors cause senescence in normal cells. Here, we show that depletion of CSB, a protein mutated in progeroid Cockayne syndrome (CS), is the earliest known trigger of p21-dependent...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6898346/ https://ncbi.nlm.nih.gov/pubmed/31811121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13314-y |
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