Challenging immunodominance of influenza-specific CD8(+) T cell responses restricted by the risk-associated HLA-A*68:01 allomorph

Although influenza viruses lead to severe illness in high-risk populations, host genetic factors associated with severe disease are largely unknown. As the HLA-A*68:01 allele can be linked to severe pandemic 2009-H1N1 disease, we investigate a potential impairment of HLA-A*68:01-restricted CD8(+) T...

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發表在:Nat Commun
Main Authors: van de Sandt, C. E., Clemens, E. B., Grant, E. J., Rowntree, L. C., Sant, S., Halim, H., Crowe, J., Cheng, A. C., Kotsimbos, T. C., Richards, M., Miller, A., Tong, S. Y. C., Rossjohn, J., Nguyen, T. H. O., Gras, S., Chen, W., Kedzierska, K.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898063/
https://ncbi.nlm.nih.gov/pubmed/31811120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13346-4
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