RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth

DNA double-strand breaks (DSBs), selectively visualized as γ-H2AX(+) foci, occur during the development of the central nervous system, including the retina, although their origin and biological significance are poorly understood. Mutant mice with DSB repair mechanism defects exhibit increased number...

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Publicado en:Sci Rep
Autores principales: Álvarez-Lindo, Noemí, Baleriola, Jimena, de los Ríos, Vivian, Suárez, Teresa, de la Rosa, Enrique J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898044/
https://ncbi.nlm.nih.gov/pubmed/31811168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54873-w
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