Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains

Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa variability could impact vaccine design. Here we identified atypical extended or truncated VAR2CSA extracellular structures and co...

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Vydáno v:Commun Biol
Hlavní autoři: Doritchamou, Justin Y. A., Morrison, Robert, Renn, Jonathan P., Ribeiro, Jose, Duan, Junhui, Fried, Michal, Duffy, Patrick E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897902/
https://ncbi.nlm.nih.gov/pubmed/31840102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0704-z
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