Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains

Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa variability could impact vaccine design. Here we identified atypical extended or truncated VAR2CSA extracellular structures and co...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Commun Biol
Egile Nagusiak: Doritchamou, Justin Y. A., Morrison, Robert, Renn, Jonathan P., Ribeiro, Jose, Duan, Junhui, Fried, Michal, Duffy, Patrick E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897902/
https://ncbi.nlm.nih.gov/pubmed/31840102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0704-z
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