Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA

Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the syncytiotrophoblast during placental malaria. This interaction facilitates placental sequestration of malaria parasites resulting in severe health outcomes for both the mother and her offspring. Furthermore, CSA...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Microbiol
Prif Awduron: Ma, Rui, Lian, Tengfei, Huang, Rick, Renn, Jonathan P., Petersen, Jennifer D., Zimmerberg, Joshua, Duffy, Patrick E., Tolia, Niraj H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914210/
https://ncbi.nlm.nih.gov/pubmed/33452495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-00858-9
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