Small-Molecule Lysophosphatidic Acid Receptor 5 (LPAR5) Antagonists: Versatile Pharmacological Tools to Regulate Inflammatory Signaling in BV-2 Microglia Cells

Lysophosphatidic acid (LPA) species in the extracellular environment induce downstream signaling via six different G protein-coupled receptors (LPAR1–6). These signaling cascades are essential for normal brain development and function of the nervous system. However, in response to acute or chronic c...

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Pubblicato in:Front Cell Neurosci
Autori principali: Plastira, Ioanna, Joshi, Lisha, Bernhart, Eva, Schoene, Jens, Specker, Edgar, Nazare, Marc, Sattler, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Cellular Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897279/
https://ncbi.nlm.nih.gov/pubmed/31849616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2019.00531
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