Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

BACKGROUND: Extracellular lysophosphatidic acid (LPA) species transmit signals via six different G protein-coupled receptors (LPAR1–6) and are indispensible for brain development and function of the nervous system. However, under neuroinflammatory conditions or brain damage, LPA levels increase, the...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Plastira, I., Bernhart, E., Goeritzer, M., DeVaney, T., Reicher, H., Hammer, A., Lohberger, B., Wintersperger, A., Zucol, B., Graier, W. F., Kratky, D., Malle, E., Sattler, W.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735906/
https://ncbi.nlm.nih.gov/pubmed/29258556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-017-1024-1
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