1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

BACKGROUND: Microglia, the immunocompetent cells of the CNS, rapidly respond to brain injury and disease by altering their morphology and phenotype to adopt an activated state. Microglia can exist broadly between two different states, namely the classical (M1) and the alternative (M2) phenotype. The...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Plastira, Ioanna, Bernhart, Eva, Goeritzer, Madeleine, Reicher, Helga, Kumble, Vishwanath Bhat, Kogelnik, Nora, Wintersperger, Andrea, Hammer, Astrid, Schlager, Stefanie, Jandl, Katharina, Heinemann, Akos, Kratky, Dagmar, Malle, Ernst, Sattler, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5002165/
https://ncbi.nlm.nih.gov/pubmed/27565558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0701-9
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