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Inhibition of KPNB1 Inhibits Proliferation and Promotes Apoptosis of Chronic Myeloid Leukemia Cells Through Regulation of E2F1

BACKGROUND: Karyopherin-β1 (KPNB1) belongs to the karyopherin superfamily, which functions as shuttling proteins from the cytoplasm to nuclear. A high level of KPNB1 has been reported in various cancers which promotes cell proliferation and inhibits apoptosis. However, the role of KPNB1 in chronic m...

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發表在:Onco Targets Ther
Main Authors: Wang, Teng, Huang, Zhenglan, Huang, Ningshu, Peng, Yuhang, Gao, Miao, Wang, Xin, Feng, Wenli
格式: Artigo
語言:Inglês
出版: Dove 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896920/
https://ncbi.nlm.nih.gov/pubmed/31819526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S210048
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