Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas

The presence of genome-wide DNA hypermethylation is a hallmark of lower grade gliomas (LGG) with isocitrate dehydrogenase (IDH) mutations. Further molecular classification of IDH mutant gliomas is defined by the presence (IDHmut-codel) or absence (IDHmut-noncodel) of hemizygous codeletion of chromos...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Al-Ali, Ruslan, Bauer, Katharina, Park, Jong-Whi, Al Abdulla, Ruba, Fermi, Valentina, von Deimling, Andreas, Herold-Mende, Christel, Mallm, Jan-Philipp, Herrmann, Carl, Wick, Wolfgang, Turcan, Şevin
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896263/
https://ncbi.nlm.nih.gov/pubmed/31806013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0851-y
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