Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation

DNA mismatches are highly polymorphic and dynamic in nature, albeit poorly characterized structurally. We utilized the antitumour antibiotic Co(II)(Chro)(2) (Chro = chromomycin A3) to stabilize the palindromic duplex d(TTGGCGAA) DNA with two G:G mismatches, allowing X-ray crystallography-based monit...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Satange, Roshan, Chuang, Chien-Ying, Neidle, Stephen, Hou, Ming-Hon
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895262/
https://ncbi.nlm.nih.gov/pubmed/31361900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz653
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