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Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA
The potent DNA-binding compound triaminotriazine-acridine conjugate (Z1) functions by targeting T:T mismatches in CTG trinucleotide repeats (TNR) that are responsible for causing neurological diseases such as myotonic dystrophy type 1 (DM1), but its binding mechanism remains unclear. We solved a cry...
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| Izdano u: | J Am Chem Soc |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7837310/ https://ncbi.nlm.nih.gov/pubmed/32478511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c03591 |
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