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Structural basis for targeting T:T mismatch with triaminotriazine-acridine conjugate induces a U-shaped head-to-head four-way junction in CTG repeat DNA

The potent DNA-binding compound triaminotriazine-acridine conjugate (Z1) functions by targeting T:T mismatches in CTG trinucleotide repeats (TNR) that are responsible for causing neurological diseases such as myotonic dystrophy type 1 (DM1), but its binding mechanism remains unclear. We solved a cry...

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Bibliografski detalji
Izdano u:J Am Chem Soc
Glavni autori: Chien, Ching-Ming, Wu, Pei-Ching, Satange, Roshan, Chang, Cheng-Chun, Lai, Zi-Lun, Hagler, Lauren D., Zimmerman, Steven C., Hou, Ming-Hon
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7837310/
https://ncbi.nlm.nih.gov/pubmed/32478511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c03591
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