MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues. Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease (AD). However, the role of MKP-1 in A...

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Publicat a:Signal Transduct Target Ther
Autors principals: Du, Yehong, Du, Yexiang, Zhang, Yun, Huang, Zhilin, Fu, Min, Li, Junjie, Pang, Yayan, Lei, Peng, Wang, Yu Tian, Song, Weihong, He, Guiqiong, Dong, Zhifang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895219/
https://ncbi.nlm.nih.gov/pubmed/31840000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0091-4
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