MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues. Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease (AD). However, the role of MKP-1 in A...

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Veröffentlicht in:Signal Transduct Target Ther
Hauptverfasser: Du, Yehong, Du, Yexiang, Zhang, Yun, Huang, Zhilin, Fu, Min, Li, Junjie, Pang, Yayan, Lei, Peng, Wang, Yu Tian, Song, Weihong, He, Guiqiong, Dong, Zhifang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895219/
https://ncbi.nlm.nih.gov/pubmed/31840000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0091-4
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