Cryo-EM structure of the human MLL1 core complex bound to the nucleosome

Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. Despite extensive structural and biochemical studies, the molecular mechanisms whereby the MLL complexes recognize histone H...

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Dades bibliogràfiques
Publicat a:Nat Commun
Autors principals: Park, Sang Ho, Ayoub, Alex, Lee, Young-Tae, Xu, Jing, Kim, Hanseong, Zheng, Wei, Zhang, Biao, Sha, Liang, An, Sojin, Zhang, Yang, Cianfrocco, Michael A., Su, Min, Dou, Yali, Cho, Uhn-Soo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895043/
https://ncbi.nlm.nih.gov/pubmed/31804488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13550-2
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