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Cryo-EM structure of the human MLL1 core complex bound to the nucleosome
Mixed lineage leukemia (MLL) family histone methyltransferases are enzymes that deposit histone H3 Lys4 (K4) mono-/di-/tri-methylation and regulate gene expression in mammals. Despite extensive structural and biochemical studies, the molecular mechanisms whereby the MLL complexes recognize histone H...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6895043/ https://ncbi.nlm.nih.gov/pubmed/31804488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13550-2 |
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