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Sodium valproate rescues expression of TRANK1 in iPSC-derived neural cells that carry a genetic variant associated with serious mental illness

Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human induced pluripotent stem cells (hiPSC) and their neural derivatives to characterize common variants on chromosome 3p22 that have been associated by...

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Bibliografiske detaljer
Udgivet i:Mol Psychiatry
Main Authors: Jiang, Xueying, Detera-Wadleigh, Sevilla D, Akula, Nirmala, Mallon, Barbara S., Hou, Liping, Xiao, Tiaojiang, Felsenfeld, Gary, Gu, Xinglong, McMahon, Francis J.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894932/
https://ncbi.nlm.nih.gov/pubmed/30135510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0207-1
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