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Impact of Sequence Specificity of Spherical Nucleic Acids on Macrophage Activation in Vitro and in Vivo

The effects of spherical nucleic acid (SNA) gold nanoparticle conjugates on the activation of macrophages in vitro and release of cytokines in vivo were explored. Herein, we show that G-quadruplexes, the formation of which is enhanced on gold nanoparticle surfaces, elicit an increase in cytokine rel...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Guan, Chenxia M., Chinen, Alyssa B., Ferrer, Jennifer R., Ko, Caroline H., Mirkin, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894393/
https://ncbi.nlm.nih.gov/pubmed/31536368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.9b00561
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