Using the K/BxN mouse model of endogenous, chronic, rheumatoid arthritis for the evaluation of potential immunoglobulin-based therapeutic agents, including IVIg and Fc-μTP-L309C, a recombinant IgG1 Fc hexamer

BACKGROUND: High-dose intravenous immunoglobulin (IVIg), and more recently, subcutaneously-delivered Ig (SCIg), are used to treat a variety of autoimmune diseases; however, there are challenges associated with product production, availability, access and efficacy. These challenges have provided ince...

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Pubblicato in:BMC Immunol
Autori principali: Lewis, Bonnie J. B., Ville, Jade, Blacquiere, Megan, Cen, Selena, Spirig, Rolf, Zuercher, Adrian W., Käsermann, Fabian, Branch, Donald R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894239/
https://ncbi.nlm.nih.gov/pubmed/31801459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-019-0328-6
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