Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape

Cells of the adult nucleus pulposus (NP) are critically important in maintaining overall disc health and function. NP cells reside in a soft, gelatinous matrix that dehydrates and becomes increasingly fibrotic with age. Such changes result in physical cues of matrix stiffness that may be potent regu...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:FASEB J
Autori principali: Fearing, Bailey V., Jing, Liufang, Barcellona, Marcos N., Witte, Savannah Est, Buchowski, Jacob M., Zebala, Lukas P., Kelly, Michael P., Luhmann, Scott, Gupta, Munish C., Pathak, Amit, Setton, Lori A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894097/
https://ncbi.nlm.nih.gov/pubmed/31638828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802725RRR
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