N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl–coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues remained elusive. Therefore, we characterized...

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Détails bibliographiques
Publié dans:FASEB J
Auteurs principaux: Hofer, Dina C., Zirkovits, Gabriel, Pelzmann, Helmut J., Huber, Katharina, Pessentheiner, Ariane R., Xia, Wenmin, Uno, Kyosuke, Miyazaki, Toh, Kon, Kanta, Tsuneki, Hiroshi, Pendl, Tobias, Al Zoughbi, Wael, Madreiter-Sokolowski, Corina T., Trausinger, Gert, Abdellatif, Mahmoud, Schoiswohl, Gabriele, Schreiber, Renate, Eisenberg, Tobias, Magnes, Christoph, Sedej, Simon, Eckhardt, Matthias, Sasahara, Masakiyo, Sasaoka, Toshiyasu, Nitta, Atsumi, Hoefler, Gerald, Graier, Wolfgang F., Kratky, Dagmar, Auwerx, Johan, Bogner-Strauss, Juliane G.
Format: Artigo
Langue:Inglês
Publié: Federation of American Societies for Experimental Biology 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894082/
https://ncbi.nlm.nih.gov/pubmed/31638418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801323R
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