N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl–coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues remained elusive. Therefore, we characterized...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Hofer, Dina C., Zirkovits, Gabriel, Pelzmann, Helmut J., Huber, Katharina, Pessentheiner, Ariane R., Xia, Wenmin, Uno, Kyosuke, Miyazaki, Toh, Kon, Kanta, Tsuneki, Hiroshi, Pendl, Tobias, Al Zoughbi, Wael, Madreiter-Sokolowski, Corina T., Trausinger, Gert, Abdellatif, Mahmoud, Schoiswohl, Gabriele, Schreiber, Renate, Eisenberg, Tobias, Magnes, Christoph, Sedej, Simon, Eckhardt, Matthias, Sasahara, Masakiyo, Sasaoka, Toshiyasu, Nitta, Atsumi, Hoefler, Gerald, Graier, Wolfgang F., Kratky, Dagmar, Auwerx, Johan, Bogner-Strauss, Juliane G.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894082/
https://ncbi.nlm.nih.gov/pubmed/31638418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801323R
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