Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling

Voltage-gated potassium (K(+)) channel subfamily B member 1 (KCNB1, Kv2.1) and integrin-α5 form macromolecular complexes—named integrin-α5-KCNB1 complexes (IKCs)—in the human brain, but their function was poorly understood. Here we report that membrane depolarization triggered IKC intracellular sign...

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Veröffentlicht in:FASEB J
Hauptverfasser: Yu, Wei, Shin, Mi Ryung, Sesti, Federico
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894052/
https://ncbi.nlm.nih.gov/pubmed/31682765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901792R
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