Transcriptional profiling of human intestinal plasma cells reveals effector functions beyond antibody production

BACKGROUND: Plasma cells (PCs) are terminally differentiated B-lymphocytes producing antibodies. In coeliac disease (CeD) there is increased density of PCs in the small-intestinal lesion. Many of these PCs produce disease-specific autoantibodies targeting transglutaminase 2 (TG2). OBJECTIVE: The pla...

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Veröffentlicht in:United European Gastroenterol J
Hauptverfasser: Snir, Omri, Kanduri, Chakravarthi, Lundin, Knut E A, Sandve, Geir Kjetil, Sollid, Ludvig M
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893993/
https://ncbi.nlm.nih.gov/pubmed/31839965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2050640619862461
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