Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue. Matrine is an alkaloid extracted from the herb root of a traditional Chinese medicine, Sophora flavescens Ait. Matrine has been reported...

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Vydáno v:Front Pharmacol
Hlavní autoři: Hong, Xiaoting, Zhong, Linhai, Xie, Yurou, Zheng, Kaifeng, Pang, Jinglong, Li, Yesen, Yang, Yifan, Xu, Xiaolin, Mi, Panying, Cao, Hanwei, Zhang, Wenqing, Hu, Tianhui, Song, Gang, Wang, Daxuan, Zhan, Yan-yan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892950/
https://ncbi.nlm.nih.gov/pubmed/31849679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01437
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