Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs). This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using patient samples and a mouse model, we...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Knackstedt, Sebastian Lorenz, Georgiadou, Athina, Apel, Falko, Abu-Abed, Ulrike, Moxon, Christopher A., Cunnington, Aubrey J., Raupach, Bärbel, Cunningham, Deirdre, Langhorne, Jean, Krüger, Renate, Barrera, Valentina, Harding, Simon P., Berg, Aase, Patel, Sam, Otterdal, Kari, Mordmüller, Benjamin, Schwarzer, Evelin, Brinkmann, Volker, Zychlinsky, Arturo, Amulic, Borko
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892640/
https://ncbi.nlm.nih.gov/pubmed/31628160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw0336
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