Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs). This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using patient samples and a mouse model, we...

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Pubblicato in:Sci Immunol
Autori principali: Knackstedt, Sebastian Lorenz, Georgiadou, Athina, Apel, Falko, Abu-Abed, Ulrike, Moxon, Christopher A., Cunnington, Aubrey J., Raupach, Bärbel, Cunningham, Deirdre, Langhorne, Jean, Krüger, Renate, Barrera, Valentina, Harding, Simon P., Berg, Aase, Patel, Sam, Otterdal, Kari, Mordmüller, Benjamin, Schwarzer, Evelin, Brinkmann, Volker, Zychlinsky, Arturo, Amulic, Borko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892640/
https://ncbi.nlm.nih.gov/pubmed/31628160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw0336
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