Neutrophil extracellular traps drive inflammatory pathogenesis in malaria

Neutrophils are essential innate immune cells that extrude chromatin in the form of neutrophil extracellular traps (NETs). This form of cell death has potent immunostimulatory activity. We show that heme-induced NETs are essential for malaria pathogenesis. Using patient samples and a mouse model, we...

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Publicado en:Sci Immunol
Autores principales: Knackstedt, Sebastian Lorenz, Georgiadou, Athina, Apel, Falko, Abu-Abed, Ulrike, Moxon, Christopher A., Cunnington, Aubrey J., Raupach, Bärbel, Cunningham, Deirdre, Langhorne, Jean, Krüger, Renate, Barrera, Valentina, Harding, Simon P., Berg, Aase, Patel, Sam, Otterdal, Kari, Mordmüller, Benjamin, Schwarzer, Evelin, Brinkmann, Volker, Zychlinsky, Arturo, Amulic, Borko
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892640/
https://ncbi.nlm.nih.gov/pubmed/31628160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw0336
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