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Glioblastoma Model Using Human Cerebral Organoids
We have developed a cancer model of gliomas in human cerebral organoids that allows direct observation of tumor initiation as well as continuous microscopic observations. We used CRISPR/Cas9 technology to target an HRas(G12V)-IRES-tdTomato construct by homologous recombination into the TP53 locus. R...
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| Veröffentlicht in: | Cell Rep |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6892608/ https://ncbi.nlm.nih.gov/pubmed/29694897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.03.105 |
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