Modeling Patient-Derived Glioblastoma with Cerebral Organoids

The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a “normal” human microenvironment and the inability of many tumor cell lines to accurately reproduce GBM biology. To address...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Linkous, Amanda, Balamatsias, Demosthenes, Snuderl, Matija, Edwards, Lincoln, Miyaguchi, Ken, Milner, Teresa, Reich, Batsheva, Cohen-Gould, Leona, Storaska, Andrew, Nakayama, Yasumi, Schenkein, Emily, Singhania, Richa, Cirigliano, Stefano, Magdeldin, Tarig, Lin, Ying, Nanjangud, Gouri, Chadalavada, Kalyani, Pisapia, David, Liston, Conor, Fine, Howard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625753/
https://ncbi.nlm.nih.gov/pubmed/30893594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.02.063
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