A New Chemotype with Promise against Trypanosoma cruzi

Pyridyl benzamide 2 is a potent inhibitor of Trypanosoma cruzi, but not other protozoan parasites, and had a selectivity-index of ≥10. The initial structure-activity relationship (SAR) indicates that benzamide and sulfonamide functional groups, and N-methylpiperazine and sterically unhindered 3-pyri...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioorg Med Chem Lett
Main Authors: Wang, Xiaofang, Cal, Monica, Kaiser, Marcel, Buckner, Frederick S., Lepesheva, Galina I., Sanford, Austin G., Wallick, Alexander I., Davis, Paul H., Vennerstrom, Jonathan L.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892603/
https://ncbi.nlm.nih.gov/pubmed/31706668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126778
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