Non-invasive detection of microsatellite instability and high tumor mutation burden in cancer patients treated with PD-1 blockade

PURPOSE: Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune checkpoint blockade; however, real-time sequencing of unresectable or metastatic solid tumors is often challenging. We report a non...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Georgiadis, Andrew, Durham, Jennifer N., Keefer, Laurel A., Bartlett, Bjarne R., Zielonka, Magdalena, Murphy, Derek, White, James R., Lu, Steve, Verner, Ellen L., Ruan, Finey, Riley, David, Anders, Robert A., Gedvilaite, Erika, Angiuoli, Sam, Jones, Siân, Velculescu, Victor E., Le, Dung T., Diaz, Luis A., Sausen, Mark
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892397/
https://ncbi.nlm.nih.gov/pubmed/31506389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1372
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