Non-invasive detection of microsatellite instability and high tumor mutation burden in cancer patients treated with PD-1 blockade

PURPOSE: Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune checkpoint blockade; however, real-time sequencing of unresectable or metastatic solid tumors is often challenging. We report a non...

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Publicado en:Clin Cancer Res
Main Authors: Georgiadis, Andrew, Durham, Jennifer N., Keefer, Laurel A., Bartlett, Bjarne R., Zielonka, Magdalena, Murphy, Derek, White, James R., Lu, Steve, Verner, Ellen L., Ruan, Finey, Riley, David, Anders, Robert A., Gedvilaite, Erika, Angiuoli, Sam, Jones, Siân, Velculescu, Victor E., Le, Dung T., Diaz, Luis A., Sausen, Mark
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892397/
https://ncbi.nlm.nih.gov/pubmed/31506389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1372
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