Non-invasive detection of microsatellite instability and high tumor mutation burden in cancer patients treated with PD-1 blockade

PURPOSE: Microsatellite instability (MSI) and high tumor mutation burden (TMB-High) are promising pan-tumor biomarkers used to select patients for treatment with immune checkpoint blockade; however, real-time sequencing of unresectable or metastatic solid tumors is often challenging. We report a non...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Georgiadis, Andrew, Durham, Jennifer N., Keefer, Laurel A., Bartlett, Bjarne R., Zielonka, Magdalena, Murphy, Derek, White, James R., Lu, Steve, Verner, Ellen L., Ruan, Finey, Riley, David, Anders, Robert A., Gedvilaite, Erika, Angiuoli, Sam, Jones, Siân, Velculescu, Victor E., Le, Dung T., Diaz, Luis A., Sausen, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6892397/
https://ncbi.nlm.nih.gov/pubmed/31506389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1372
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