NKT cells co-expressing a GD2-specific chimeric antigen receptor and IL-15 show enhanced in vivo persistence and antitumor activity against neuroblastoma.

PURPOSE: Vα24-invariant natural killer T cells (NKTs) are attractive carriers for chimeric antigen receptors (CARs) due to their inherent antitumor properties and preferential localization to tumor sites. However, limited persistence of CAR-NKTs in tumor-bearing mice is associated with tumor recurre...

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Publicado no:Clin Cancer Res
Main Authors: Xu, Xin, Huang, Wei, Heczey, Andras, Liu, Daofeng, Guo, Linjie, Wood, Michael, Jin, Jingling, Courtney, Amy N., Liu, Bin, Di Pierro, Erica J., Hicks, John, Barragan, Gabriel A., Ngai, Ho, Chen, Yuhui, Savoldo, Barbara, Dotti, Gianpietro, Metelitsa, Leonid S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891170/
https://ncbi.nlm.nih.gov/pubmed/31484667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0421
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