Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

The ATR kinase is a master regulator of the cellular response to DNA replication stress. Activation of ATR relies on dual pathways involving the TopBP1 and ETAA1 proteins, both of which harbor ATR-activating domains (AADs). However, the exact contribution of the recently discovered ETAA1 pathway to...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Cell Biol
Auteurs principaux: Achuthankutty, Divya, Thakur, Roshan Singh, Haahr, Peter, Hoffmann, Saskia, Drainas, Alexandros P., Bizard, Anna H., Weischenfeldt, Joachim, Hickson, Ian D., Mailand, Niels
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891097/
https://ncbi.nlm.nih.gov/pubmed/31615875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201905064
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires