Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability

The ATR kinase is a master regulator of the cellular response to DNA replication stress. Activation of ATR relies on dual pathways involving the TopBP1 and ETAA1 proteins, both of which harbor ATR-activating domains (AADs). However, the exact contribution of the recently discovered ETAA1 pathway to...

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Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Achuthankutty, Divya, Thakur, Roshan Singh, Haahr, Peter, Hoffmann, Saskia, Drainas, Alexandros P., Bizard, Anna H., Weischenfeldt, Joachim, Hickson, Ian D., Mailand, Niels
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2019
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891097/
https://ncbi.nlm.nih.gov/pubmed/31615875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201905064
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