Confinement hinders motility by inducing RhoA-mediated nuclear influx, volume expansion, and blebbing

Cells migrate in vivo through complex confining microenvironments, which induce significant nuclear deformation that may lead to nuclear blebbing and nuclear envelope rupture. While actomyosin contractility has been implicated in regulating nuclear envelope integrity, the exact mechanism remains unk...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Mistriotis, Panagiotis, Wisniewski, Emily O., Bera, Kaustav, Keys, Jeremy, Li, Yizeng, Tuntithavornwat, Soontorn, Law, Robert A., Perez-Gonzalez, Nicolas A., Erdogmus, Eda, Zhang, Yuqi, Zhao, Runchen, Sun, Sean X., Kalab, Petr, Lammerding, Jan, Konstantopoulos, Konstantinos
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891075/
https://ncbi.nlm.nih.gov/pubmed/31690619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201902057
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