Drug Repurposing of Bromodomain Inhibitors as Potential Novel Therapeutic Leads for Lymphatic Filariasis Guided by Multispecies Transcriptomics

To better understand the transcriptomic interplay of organisms associated with lymphatic filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial nematode Brugia malayi, its Wolbachia endosymbiont wBm, and its laboratory vector Aedes aegypti across the entire B. malay...

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Vydáno v:mSystems
Hlavní autoři: Chung, Matthew, Teigen, Laura E., Libro, Silvia, Bromley, Robin E., Olley, Dustin, Kumar, Nikhil, Sadzewicz, Lisa, Tallon, Luke J., Mahurkar, Anup, Foster, Jeremy M., Michalski, Michelle L., Dunning Hotopp, Julie C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890932/
https://ncbi.nlm.nih.gov/pubmed/31796568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00596-19
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