Sodium valproate and 5-aza-2′-deoxycytidine differentially modulate DNA demethylation in G1 phase-arrested and proliferative HeLa cells

Sodium valproate/valproic acid (VPA), a histone deacetylase inhibitor, and 5-aza-2-deoxycytidine (5-aza-CdR), a DNA methyltransferase 1 (DNMT1) inhibitor, induce DNA demethylation in several cell types. In HeLa cells, although VPA leads to decreased DNA 5-methylcytosine (5mC) levels, the demethylati...

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Publicado no:Sci Rep
Main Authors: Rocha, Marina Amorim, Veronezi, Giovana Maria Breda, Felisbino, Marina Barreto, Gatti, Maria Silvia Viccari, Tamashiro, Wirla M. S. C., Mello, Maria Luiza Silveira
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890691/
https://ncbi.nlm.nih.gov/pubmed/31796828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-54848-x
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