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Chromatin Remodeling, Cell Proliferation and Cell Death in Valproic Acid-Treated HeLa Cells
BACKGROUND: Valproic acid (VPA) is a potent anticonvulsant that inhibits histone deacetylases. Because of this inhibitory action, we investigated whether VPA would affect chromatin supraorganization, mitotic indices and the frequency of chromosome abnormalities and cell death in HeLa cells. METHODOL...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3242782/ https://ncbi.nlm.nih.gov/pubmed/22206001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029144 |
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