Repression of phagocytosis by human CD33 is not conserved with mouse CD33

CD33 is an immunomodulatory receptor linked to Alzheimer’s disease (AD) susceptibility via regulation of phagocytosis in microglia. Divergent features between human CD33 (hCD33) and murine CD33 (mCD33) include a unique transmembrane lysine in mCD33 and cytoplasmic tyrosine in hCD33. The functional c...

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Publicado no:Commun Biol
Main Authors: Bhattacherjee, Abhishek, Rodrigues, Emily, Jung, Jaesoo, Luzentales-Simpson, Matthew, Enterina, Jhon R., Galleguillos, Danny, St. Laurent, Chris D., Nakhaei-Nejad, Maryam, Fuchsberger, Felix F., Streith, Laura, Wang, Qian, Kawasaki, Norihito, Duan, Shiteng, Bains, Arjun, Paulson, James C., Rademacher, Christoph, Giuliani, Fabrizio, Sipione, Simonetta, Macauley, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890642/
https://ncbi.nlm.nih.gov/pubmed/31815204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0698-6
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