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Mechanism of Allosteric Modulation of P-glycoprotein by Transport Substrates and Inhibitors
The ATP-binding cassette subfamily B member 1 (ABCB1) multidrug transporter P-glycoprotein plays a central role in clearance of xenobiotics in humans and is implicated in cancer resistance to chemotherapy. We used double electron electron resonance spectroscopy to uncover the basis of stimulation of...
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| Veröffentlicht in: | Science |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6890515/ https://ncbi.nlm.nih.gov/pubmed/31097669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav9406 |
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