ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type

The ALVAC-HIV clade B/AE and equivalent SIV-based/gp120 + Alum vaccines successfully decreased the risk of virus acquisition in humans and macaques. Here, we tested the efficacy of HIV clade B/C ALVAC/gp120 vaccine candidates + MF59 or different doses of Aluminum hydroxide (Alum) against SHIV-Cs of...

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Udgivet i:PLoS Pathog
Main Authors: Schifanella, Luca, Barnett, Susan W., Bissa, Massimiliano, Galli, Veronica, Doster, Melvin N., Vaccari, Monica, Tomaras, Georgia D., Shen, Xiaoying, Phogat, Sanjay, Pal, Ranajit, Montefiori, David C., LaBranche, Celia C., Rao, Mangala, Trinh, Hung V., Washington-Parks, Robyn, Liyanage, Namal P. M., Brown, Dallas R., Liang, Frank, Loré, Karin, Venzon, David J., Magnanelli, William, Metrinko, Michelle, Kramer, Josh, Breed, Matthew, Alter, Galit, Ruprecht, Ruth M., Franchini, Genoveffa
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6890176/
https://ncbi.nlm.nih.gov/pubmed/31794588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008121
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