Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIV(mac251) Acquisition

The recombinant ALVAC vaccine coupled with the monomeric gp120/alum protein have decreased the risk of HIV and SIV acquisition. Ab responses to the V1/V2 regions have correlated with a decreased risk of virus acquisition in both humans and macaques. We hypothesized that the breadth and functional pr...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Gordon, Shari N., Liyanage, Namal P. M., Doster, Melvin N., Vaccari, Monica, Vargas-Inchaustegui, Diego A., Pegu, Poonam, Schifanella, Luca, Shen, Xiaoying, Tomaras, Georgia D., Rao, Mangala, Billings, Erik A., Schwartz, Jennifer, Prado, Ilia, Bobb, Kathryn, Zhang, Wenlei, Montefiori, David C., Foulds, Kathryn E., Ferrari, Guido, Robert-Guroff, Marjorie, Roederer, Mario, Phan, Tran B., Forthal, Donald N., Stablein, Donald M., Phogat, Sanjay, Venzon, David J., Fouts, Timothy, Franchini, Genoveffa
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2016
Assuntos:
Immunotherapy and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026031/
https://ncbi.nlm.nih.gov/pubmed/27591322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600674
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