Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIV(mac251) Acquisition

The recombinant ALVAC vaccine coupled with the monomeric gp120/alum protein have decreased the risk of HIV and SIV acquisition. Ab responses to the V1/V2 regions have correlated with a decreased risk of virus acquisition in both humans and macaques. We hypothesized that the breadth and functional pr...

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Bibliographic Details
Published in:J Immunol
Main Authors: Gordon, Shari N., Liyanage, Namal P. M., Doster, Melvin N., Vaccari, Monica, Vargas-Inchaustegui, Diego A., Pegu, Poonam, Schifanella, Luca, Shen, Xiaoying, Tomaras, Georgia D., Rao, Mangala, Billings, Erik A., Schwartz, Jennifer, Prado, Ilia, Bobb, Kathryn, Zhang, Wenlei, Montefiori, David C., Foulds, Kathryn E., Ferrari, Guido, Robert-Guroff, Marjorie, Roederer, Mario, Phan, Tran B., Forthal, Donald N., Stablein, Donald M., Phogat, Sanjay, Venzon, David J., Fouts, Timothy, Franchini, Genoveffa
Format: Artigo
Language:Inglês
Published: AAI 2016
Subjects:
Immunotherapy and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026031/
https://ncbi.nlm.nih.gov/pubmed/27591322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600674
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