The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection

Clostridium difficile infection (CDI) is an antibiotic-induced microbiota shift disease of the large bowel. While there is a need for narrow-spectrum CDI antibiotics, it is unclear which cellular proteins are appropriate drug targets to specifically inhibit C. difficile. We evaluated the enoyl-acyl...

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Udgivet i:ACS Infect Dis
Main Authors: Marreddy, Ravi K.R., Wu, Xiaoqian, Sapkota, Madhab, Prior, Allan M., Jones, Jesse A., Sun, Dianqing, Hevener, Kirk E., Hurdle, Julian G.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889869/
https://ncbi.nlm.nih.gov/pubmed/30501172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.8b00205
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