A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival

Chondrosarcomas are malignant cartilage tumors that are relatively resistant towards conventional therapeutic approaches. Kinase inhibitors have been investigated and shown successful for several different cancer types. In this study we aimed at identifying kinase inhibitors that inhibit the surviva...

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Detalhes bibliográficos
Publicado no:J Bone Oncol
Main Authors: de Jong, Yvonne, Bennani, Fairuz, van Oosterwijk, Jolieke G., Alberti, Gaia, Baranski, Zuzanna, Wijers-Koster, Pauline, Venneker, Sanne, Briaire-de Bruijn, Inge H., van de Akker, Brendy E., Baelde, Hans, Cleton-Jansen, Anne-Marie, van de Water, Bob, Danen, Erik H.J., Bovée, Judith V.M.G.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889735/
https://ncbi.nlm.nih.gov/pubmed/31832331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2019.100268
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