A screening-based approach identifies cell cycle regulators AURKA, CHK1 and PLK1 as targetable regulators of chondrosarcoma cell survival

Chondrosarcomas are malignant cartilage tumors that are relatively resistant towards conventional therapeutic approaches. Kinase inhibitors have been investigated and shown successful for several different cancer types. In this study we aimed at identifying kinase inhibitors that inhibit the surviva...

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Vydáno v:J Bone Oncol
Hlavní autoři: de Jong, Yvonne, Bennani, Fairuz, van Oosterwijk, Jolieke G., Alberti, Gaia, Baranski, Zuzanna, Wijers-Koster, Pauline, Venneker, Sanne, Briaire-de Bruijn, Inge H., van de Akker, Brendy E., Baelde, Hans, Cleton-Jansen, Anne-Marie, van de Water, Bob, Danen, Erik H.J., Bovée, Judith V.M.G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889735/
https://ncbi.nlm.nih.gov/pubmed/31832331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2019.100268
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