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Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy
BACKGROUND: Protoporphyrin IX (PpIX) gets accumulated preferentially in 5-aminolevulinic acid (5-ALA)-treated cancer cells. Photodynamic therapy (PDT) utilises the accumulated PpIX to trigger cell death by light-induced generation of reactive oxygen species (ROS). We previously demonstrated that onc...
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| Publicado no: | Br J Cancer |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6889170/ https://ncbi.nlm.nih.gov/pubmed/31551581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0586-3 |
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