Systemic MEK inhibition enhances the efficacy of 5-aminolevulinic acid-photodynamic therapy

BACKGROUND: Protoporphyrin IX (PpIX) gets accumulated preferentially in 5-aminolevulinic acid (5-ALA)-treated cancer cells. Photodynamic therapy (PDT) utilises the accumulated PpIX to trigger cell death by light-induced generation of reactive oxygen species (ROS). We previously demonstrated that onc...

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Bibliografiske detaljer
Udgivet i:Br J Cancer
Main Authors: Chelakkot, Vipin Shankar, Som, Jayoti, Yoshioka, Ema, Rice, Chantel P., Rutihinda, Suzette G., Hirasawa, Kensuke
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6889170/
https://ncbi.nlm.nih.gov/pubmed/31551581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0586-3
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