MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes

The efficacy of aminolevulinic acid (5-ALA)-based photodynamic diagnosis (5-ALA-PDD) and photodynamic therapy (5-ALA-PDT) is dependent on 5-ALA-induced cancer-specific accumulation of protoporphyrin IX (PpIX). We previously reported that inhibition of oncogenic Ras/MEK increases PpIX accumulation in...

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Vydáno v:Sci Rep
Hlavní autoři: Chelakkot, Vipin Shankar, Liu, Kaiwen, Yoshioka, Ema, Saha, Shaykat, Xu, Danyang, Licursi, Maria, Dorward, Ann, Hirasawa, Kensuke
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7747616/
https://ncbi.nlm.nih.gov/pubmed/33335181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-79144-x
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